Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 17/20 | 0.62 |
| ▸ | HTR2C | P28335 | 15/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6198974 | 0.92 | HTR2A (0.60) | HTR2AHTR2CMAPTMEN1KMT2A | |
| SCHEMBL6198366 | 0.89 | HTR2A (0.73) | HTR2AHTR2C | |
| SCHEMBL6201944 | 0.84 | HTR2A (0.65) | HTR2AHTR2C | |
| SCHEMBL6198042 | 0.83 | HTR2A (0.64) | HTR2AHTR2C | |
| SCHEMBL6201230 | 0.82 | HTR2A (0.61) | HTR2AHTR2C | |
| SCHEMBL6222572 | 0.82 | HTR2A (0.56) | HTR2AHTR2CMAPTMEN1KMT2A | |
| SCHEMBL6194251 | 0.82 | HTR2A (0.61) | HTR2AHTR2C | |
| SCHEMBL6197320 | 0.80 | HTR2A (0.69) | HTR2AHTR2C | |
| SCHEMBL15248559 | 0.79 | HTR2A (0.78) | HTR2AHTR2C | |
| SCHEMBL6197155 | 0.79 | HTR2A (0.66) | HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509505-A2 | SMALL MOLECULE MODULATORS OF THE 5−HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2005-03-02 | — | — | EP | claimed |
| WO-2003062206-A2 | SMALL MOLECULE MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2003-07-31 | — | — | WO | claimed |