Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 2/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28170665 | 0.91 | CXCR4 (0.50) | CHRM5CHRM3SIGMAR1MEN1KMT2A | |
| SCHEMBL28192430 | 0.85 | — | — | |
| SCHEMBL12247559 | 0.82 | CHRM5 (0.47) | CHRM5CHRM3SIGMAR1SMN1; SMN2POLB | |
| SCHEMBL12247558 | 0.82 | CHRM5 (0.47) | CHRM5CHRM3SIGMAR1SMN1; SMN2POLB | |
| SCHEMBL24247411 | 0.80 | CHRM5 (0.55) | CHRM5CHRM3SIGMAR1SMN1; SMN2POLB | |
| SCHEMBL14199354 | 0.80 | CHRM5 (0.46) | CHRM5CHRM3SIGMAR1SMN1; SMN2POLB | |
| SCHEMBL8038 | 0.80 | CHRM5 (0.55) | CHRM5CHRM3SIGMAR1SMN1; SMN2POLB | |
| SCHEMBL1126801 | 0.80 | CHRM5 (0.46) | CHRM5CHRM3SIGMAR1SMN1; SMN2POLB | |
| SCHEMBL11229119 | 0.80 | CHRM5 (0.46) | CHRM5CHRM3SIGMAR1SMN1; SMN2POLB | |
| SCHEMBL20038018 | 0.78 | MAPT (0.46) | CHRM5CHRM3SIGMAR1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 338 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108602829-A | Cxcr4 receptor antagonists | 百时美施贵宝公司 | 2018-09-28 | — | — | CN | claimed |
| CN-108440528-A | Fourth Ring Bu Luomo structural domain inhibitor | 艾伯维公司 | 2018-08-24 | — | — | CN | claimed |
| CN-108440505-A | The total synthesis method of eptapirone | 中南大学 | 2018-08-24 | — | — | CN | claimed |
| CN-108349874-A | Compounds with BLT inhibitory activity and include its composition for preventing or treating diseases associated with inflammation as active constituent | 东国大学校产学协力团 | 2018-07-31 | — | — | CN | claimed |
| CN-104470913-B | Process for the manufacture of hydroxylated cyclopentylpyrimidine compounds | 阵列生物制药公司 | 2018-07-20 | — | — | CN | claimed |
| CN-108047162-A | Diaryl sulfoxide and sulfone derivative, and preparation method and application thereof | 中山万远新药研发有限公司 | 2018-05-18 | — | — | CN | claimed |
| CN-108047165-A | A kind of benzoate compounds and preparation method and application | 天津科技大学 | 2018-05-18 | — | — | CN | claimed |
| CN-105026403-B | Tetracyclic Bromodomain Inhibitors | 艾伯维公司 | 2018-05-18 | — | — | CN | claimed |
| CN-107624113-A | Tetrahydropyridopyrimidines and tetrahydropyridopyridines as inhibitors of HBsAg (HBV surface antigen) and HBV DNA production for the treatment of hepatitis B virus infection | 豪夫迈·罗氏有限公司 | 2018-01-23 | — | — | CN | claimed |
| CN-107250120-A | 1,3, 4-thiadiazol-2-yl-benzamide derivatives as inhibitors of the Wnt signaling pathway | 拜耳制药股份公司 | 2017-10-13 | — | — | CN | claimed |
| CN-105143221-B | Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders | 加拉帕戈斯股份有限公司 | 2017-06-09 | — | — | CN | claimed |
| CN-105037399-B | Bcr-Abl amphiploid inhibitor, preparation method and application thereof | 深圳永泽医药股份有限公司 | 2017-04-26 | — | — | CN | claimed |
| CN-102056927-A | Fused nitrogen containing heterocycles and compositions thereof as kinase inhibitors | IRM LLC | 2011-05-11 | — | — | CN | claimed |
| CN-110446710-A | PROCESS FOR PREPARING BTK INHIBITORS | H HOFFMANN LA ROCHE AG | 2019-11-12 | — | — | CN | disclosed |
| CN-110366550-A | Benzoisothiazole, isothiazolo [3,4-b ] pyridine, quinazoline, phthalazine, pyrido [2,3-d ] pyridazine and pyrido [2,3-d ] pyrimidine derivatives as KRAS G12C inhibitors for the treatment of lung, pancreatic or colorectal cancer | 美国安进公司 | 2019-10-22 | — | — | CN | disclosed |
| CN-105793262-B | Two cycloalkyne derivatives and application thereof | 新加坡科技研究局 | 2019-09-03 | — | — | CN | disclosed |
| EP-0450066-B1 | CARBOSTYRIL DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 1996-09-11 | — | — | EP | disclosed |
| US-5401740-A | FOR INHIBITING PLATELET AGGREGATION | OTSUKA PHARMACEUTICAL CO. (JP) | 1995-03-28 | — | — | US | disclosed |
| US-5227381-A | Anticoagulant | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-07-13 | — | — | US | disclosed |
| EP-0513387-A1 | ACTIVE OXYGEN INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-19 | — | — | EP | disclosed |