Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.55 |
| ▸ | DRD2 | P14416 | 3/20 | 0.55 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 2/20 | 0.50 |
| ▸ | CCR3 | P51677 | 2/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.47 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.47 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.45 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.45 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6199812 | 0.95 | UTS2R (0.59) | UTS2RDRD2TMEM97SIGMAR1ADRA2A | |
| SCHEMBL6197401 | 0.94 | UTS2R (0.59) | UTS2RDRD2TMEM97SIGMAR1ADRA2A | |
| SCHEMBL6194976 | 0.93 | UTS2R (0.56) | UTS2RDRD2TMEM97SIGMAR1ADRA2A | |
| SCHEMBL6195133 | 0.91 | UTS2R (0.55) | UTS2RDRD2TMEM97SIGMAR1ADRA2A | |
| SCHEMBL6199808 | 0.91 | UTS2R (0.55) | UTS2RDRD2TMEM97SIGMAR1ADRA2A | |
| SCHEMBL6199511 | 0.91 | UTS2R (0.56) | UTS2RDRD2TMEM97SIGMAR1ADRA2A | |
| SCHEMBL6195622 | 0.90 | UTS2R (0.56) | UTS2RDRD2TMEM97SIGMAR1ADRA2A | |
| SCHEMBL6197610 | 0.90 | UTS2R (0.58) | UTS2RDRD2TMEM97SIGMAR1ADRA2A | |
| SCHEMBL6199235 | 0.90 | UTS2R (0.53) | UTS2RDRD2TMEM97SIGMAR1ADRA2A | |
| SCHEMBL6210485 | 0.89 | UTS2R (0.55) | UTS2RDRD2TMEM97SIGMAR1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499607-B1 | 4-(PIPERIDYL- AND PYRROLIDYL-ALKYL-UREIDO)-QUINOLINES AS UROTENSIN II RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2005-12-07 | — | — | EP | disclosed |