Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 5/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4858117 | 0.95 | UTS2R (0.58) | UTS2RSIGMAR1ADRA2ADRD2SLC6A2 | |
| SCHEMBL6200372 | 0.93 | UTS2R (0.55) | UTS2RSIGMAR1ADRA2ADRD2SLC6A2 | |
| SCHEMBL6196060 | 0.90 | UTS2R (0.62) | UTS2RSIGMAR1ADRA2ADRD2SLC6A2 | |
| SCHEMBL6195795 | 0.88 | UTS2R (0.61) | UTS2RSIGMAR1ADRA2ADRD2SLC6A2 | |
| SCHEMBL6196322 | 0.88 | UTS2R (0.58) | UTS2RSIGMAR1ADRA2ADRD2SLC6A2 | |
| SCHEMBL6196386 | 0.88 | UTS2R (0.57) | UTS2RSIGMAR1ADRA2ADRD2SLC6A2 | |
| SCHEMBL6194636 | 0.88 | UTS2R (0.59) | UTS2RSIGMAR1ADRA2ADRD2SLC6A2 | |
| SCHEMBL6196937 | 0.87 | UTS2R (0.57) | UTS2RSIGMAR1ADRA2ADRD2SLC6A2 | |
| SCHEMBL6197953 | 0.87 | UTS2R (0.65) | UTS2RSIGMAR1ADRA2ADRD2SLC6A2 | |
| SCHEMBL6197401 | 0.87 | UTS2R (0.59) | UTS2RSIGMAR1ADRA2ADRD2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499607-B1 | 4-(PIPERIDYL- AND PYRROLIDYL-ALKYL-UREIDO)-QUINOLINES AS UROTENSIN II RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2005-12-07 | — | — | EP | disclosed |