SCHEMBL6199859

SCHEMBL6199859

CCCCS(=O)(=O)c1ccc(CNC(=O)c2ccc(C)n(-c3cccc(C(F)(F)F)c3)c2=O)cc1.Cc1ccc(C(=O)NCc2ccc(S(=O)(=O)CC(C)C)cc2)c(=O)n1-c1cccc(C(F)(F)F)c1

nearest known ligand 0.70

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ELANE P08246 19/20 0.70
RORC P51449 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5757433 0.94 ELANE (0.78) ELANE
SCHEMBL5756558 0.94 ELANE (0.79) ELANE
SCHEMBL5756221 0.90 ELANE (0.80) ELANE
SCHEMBL5758038 0.89 ELANE (0.77) ELANE
SCHEMBL5756150 0.88 ELANE (0.78) ELANE
SCHEMBL5756313 0.87 ELANE (0.84) ELANERORC
SCHEMBL5757714 0.87 ELANE (0.73) ELANE
SCHEMBL5759377 0.86 ELANE (0.80) ELANE
SCHEMBL5931077 0.85 ELANE (0.73) ELANE
SCHEMBL8234299 0.84 ELANE (0.71) ELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1562902-A1 2-PYRIDONE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE AstraZeneca AB (SE) 2005-08-17 EP disclosed
WO-2004043924-A1 2-PYRIDONE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE ASTRAZENECA AB (SE) 2004-05-27 WO disclosed