Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6198833 | 0.91 | HTT (0.38) | HTTSMN1; SMN2MEN1ALDH1A1HPGD | |
| SCHEMBL6196690 | 0.90 | HTT (0.37) | HTTSMN1; SMN2MEN1ALDH1A1HPGD | |
| SCHEMBL6196257 | 0.89 | HTT (0.38) | HTTSMN1; SMN2MEN1ALDH1A1HPGD | |
| SCHEMBL6197495 | 0.88 | HTT (0.35) | HTTSMN1; SMN2MEN1ALDH1A1HPGD | |
| SCHEMBL6198184 | 0.87 | HTT (0.38) | HTTSMN1; SMN2MEN1ALDH1A1HPGD | |
| SCHEMBL6193994 | 0.86 | HTT (0.39) | HTTSMN1; SMN2MEN1ALDH1A1HPGD | |
| SCHEMBL6195720 | 0.86 | HTT (0.36) | HTTSMN1; SMN2MEN1ALDH1A1HPGD | |
| SCHEMBL6198464 | 0.86 | HTT (0.43) | HTTSMN1; SMN2MEN1ALDH1A1HPGD | |
| SCHEMBL6196593 | 0.86 | SMN1; SMN2 (0.35) | HTTSMN1; SMN2MEN1ALDH1A1HPGD | |
| SCHEMBL6196795 | 0.86 | NPSR1 (0.42) | HTTSMN1; SMN2MEN1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0768302-B1 | Hydroxypyridinones | NOVARTIS AG (CH) | 2005-07-06 | — | — | EP | disclosed |
| US-5688815-A | COMPOUNDS FOR REMOVAL OF EXCESS IRON IN MAMMALS | CIBA GEIGY CORPORATION (US) | 1997-11-18 | — | — | US | disclosed |
| EP-0768302-A2 | Hydroxypyridinones | Novartis AG (CH) | 1997-04-16 | — | — | EP | disclosed |