Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | KDM6A | O15550 | 1/20 | 0.50 |
| ▸ | KDM4A | O75164 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | KDM5C | P41229 | 1/20 | 0.50 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.50 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.50 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.50 |
| ▸ | COMT | P21964 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6200311 | 0.86 | KDM4E (0.45) | KDM4ECYP2C19KDM6AKDM4ACYP2C9 | |
| SCHEMBL6201007 | 0.86 | KDM4E (0.45) | KDM4ECYP2C19KDM6AKDM4ACYP2C9 | |
| SCHEMBL6193484 | 0.86 | KDM4E (0.47) | KDM4ECYP2C19KDM6AKDM4ACYP2C9 | |
| SCHEMBL6197600 | 0.81 | KDM4E (0.37) | KDM4ECYP2C19KDM6AKDM4ACYP2C9 | |
| SCHEMBL2608129 | 0.78 | KDM4E (0.57) | KDM4ECYP2C19KDM6AKDM4ACYP2C9 | |
| SCHEMBL8851069 | 0.76 | KDM4E (0.36) | KDM4ECYP2C19KDM6AKDM4ACYP2C9 | |
| SCHEMBL13555534 | 0.76 | KDM4E (0.55) | KDM4ECYP2C19KDM6AKDM4ACYP2C9 | |
| SCHEMBL6200148 | 0.76 | SMN1; SMN2 (0.46) | KDM4ECYP2C19KDM6AKDM4ACYP2C9 | |
| SCHEMBL6194984 | 0.76 | MAPK1 (0.45) | KDM4ECYP2C19KDM6AKDM4ACYP2C9 | |
| SCHEMBL8851078 | 0.74 | COMT (0.33) | KDM4ECYP2C19KDM6AKDM4ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0768302-B1 | Hydroxypyridinones | NOVARTIS AG (CH) | 2005-07-06 | — | — | EP | disclosed |
| US-5688815-A | COMPOUNDS FOR REMOVAL OF EXCESS IRON IN MAMMALS | CIBA GEIGY CORPORATION (US) | 1997-11-18 | — | — | US | disclosed |
| EP-0768302-A2 | Hydroxypyridinones | Novartis AG (CH) | 1997-04-16 | — | — | EP | disclosed |