Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 6/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3587341 | 0.91 | KMT2A (1.00) | KMT2AALDH1A1CYP2D6PDE5APKM | |
| SCHEMBL6441707 | 0.91 | KMT2A (1.00) | KMT2AALDH1A1CYP2D6PDE5APKM | |
| Hydrochloric Acid SCHEMBL6386723 | 0.90 | KMT2A (0.98) | KMT2AALDH1A1CYP2D6PDE5APKM | |
| Hydrochloric Acid SCHEMBL6442412 | 0.90 | KMT2A (0.98) | KMT2AALDH1A1CYP2D6PDE5APKM | |
| SCHEMBL6441696 | 0.90 | KMT2A (0.98) | KMT2AALDH1A1CYP2D6PDE5APKM | |
| SCHEMBL6444417 | 0.89 | KMT2A (0.83) | KMT2AALDH1A1CYP2D6PDE5APKM | |
| Hydrochloric Acid SCHEMBL6446785 | 0.88 | KMT2A (0.78) | KMT2AALDH1A1CYP2D6PDE5APKM | |
| Hydrochloric Acid SCHEMBL6447417 | 0.87 | KMT2A (0.77) | KMT2AALDH1A1CYP2D6PDE5APKM | |
| Hydrochloric Acid SCHEMBL7388188 | 0.87 | KMT2A (0.92) | KMT2AALDH1A1CYP2D6PDE5APKM | |
| SCHEMBL6444662 | 0.86 | KMT2A (0.72) | KMT2AALDH1A1CYP2D6PDE5APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1092720-B1 | Process for the preparation of pyrazolo [4,3-d] pyrimidin-7-ones-3-pyridylsulphonyl compounds and intermediates thereof | PFIZER LTD (GB) | 2005-01-12 | — | — | EP | disclosed |
| EP-1092720-A2 | Process for the preparation of pyrazolo [4,3-d] pyrimidin-7-ones-3-pyridylsulphonyl compounds and intermediates thereof | Pfizer Limited (GB) | 2001-04-18 | — | — | EP | disclosed |