Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 15/20 | 1.00 |
| ▸ | HTR2C | P28335 | 13/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6196807 | 0.89 | HTR2A (0.80) | HTR2AHTR2CNPC1RAB9AMAPT | |
| SCHEMBL6198605 | 0.87 | HTR2A (0.76) | HTR2AHTR2CMAPTHTTKDR | |
| SCHEMBL5946688 | 0.86 | HTR2A (0.76) | HTR2AHTR2CKDR | |
| SCHEMBL6197991 | 0.86 | HTR2A (0.75) | HTR2AHTR2CNPC1RAB9AMAPT | |
| SCHEMBL15248521 | 0.84 | HTR2A (0.72) | HTR2AHTR2C | |
| SCHEMBL6201549 | 0.84 | HTR2A (0.72) | HTR2AHTR2C | |
| SCHEMBL6198959 | 0.83 | HTR2A (0.77) | HTR2AHTR2CNPC1RAB9AMAPT | |
| SCHEMBL6201624 | 0.83 | HTR2A (1.00) | HTR2AHTR2C | |
| SCHEMBL5057434 | 0.82 | HTR2A (0.81) | HTR2AHTR2C | |
| SCHEMBL6199703 | 0.82 | HTR2A (0.78) | HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509505-A2 | SMALL MOLECULE MODULATORS OF THE 5−HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2005-03-02 | — | — | EP | claimed |
| WO-2003062206-A2 | SMALL MOLECULE MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2003-07-31 | — | — | WO | claimed |