Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 17/20 | 0.72 |
| ▸ | HTR2C | P28335 | 15/20 | 0.50 |
| ▸ | PNPLA2 | Q96AD5 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6196368 | 0.90 | HTR2A (0.58) | HTR2AHTR2CPNPLA2HDAC6 | |
| SCHEMBL6200665 | 0.90 | HTR2A (0.57) | HTR2AHTR2CPNPLA2HDAC6ALDH1A1 | |
| SCHEMBL6197991 | 0.85 | HTR2A (0.75) | HTR2AHTR2CMAPT | |
| SCHEMBL6201624 | 0.84 | HTR2A (1.00) | HTR2AHTR2CCNR1 | |
| SCHEMBL6201055 | 0.83 | HTR2A (0.78) | HTR2AHTR2CALDH1A1MAPTHPGD | |
| SCHEMBL6197615 | 0.82 | HTR2A (0.48) | HTR2AHTR2CPNPLA2HDAC6ALDH1A1 | |
| SCHEMBL6197652 | 0.81 | HTR2A (0.68) | HTR2AHTR2C | |
| SCHEMBL6200786 | 0.80 | HTR2A (0.77) | HTR2AHTR2CMAPTCNR1 | |
| SCHEMBL6197646 | 0.80 | HTR2A (0.80) | HTR2AHTR2CCNR1 | |
| SCHEMBL6670281 | 0.79 | HTR2A (0.71) | HTR2AHTR2CALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509505-A2 | SMALL MOLECULE MODULATORS OF THE 5−HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2005-03-02 | — | — | EP | claimed |
| WO-2003062206-A2 | SMALL MOLECULE MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2003-07-31 | — | — | WO | claimed |