Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 13/20 | 0.62 |
| ▸ | HTR2C | P28335 | 11/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6198147 | 0.93 | HTR2A (0.63) | HTR2AHTR2CCYP1A2 | |
| SCHEMBL5063284 | 0.92 | HTR2A (0.62) | HTR2AHTR2CALDH1A1 | |
| SCHEMBL6200081 | 0.91 | HTR2A (0.63) | HTR2AHTR2C | |
| SCHEMBL6194839 | 0.87 | HTR2A (0.57) | HTR2AHTR2C | |
| SCHEMBL6199926 | 0.84 | HTR2A (0.63) | HTR2AHTR2CALDH1A1MAPK1 | |
| SCHEMBL6248190 | 0.83 | HTR2A (0.62) | HTR2AHTR2C | |
| SCHEMBL6200102 | 0.82 | HTR2A (0.59) | HTR2AHTR2C | |
| SCHEMBL6201248 | 0.81 | HTR2A (0.63) | HTR2AHTR2C | |
| SCHEMBL6200979 | 0.81 | HTR2A (0.63) | HTR2AHTR2C | |
| SCHEMBL6197004 | 0.81 | HTR2A (0.62) | HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509505-A2 | SMALL MOLECULE MODULATORS OF THE 5−HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2005-03-02 | — | — | EP | claimed |
| WO-2003062206-A2 | SMALL MOLECULE MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2003-07-31 | — | — | WO | claimed |