Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 18/20 | 0.69 |
| ▸ | HDAC3 | O15379 | 13/20 | 0.69 |
| ▸ | HDAC4 | P56524 | 13/20 | 0.69 |
| ▸ | HDAC7 | Q8WUI4 | 13/20 | 0.69 |
| ▸ | HDAC2 | Q92769 | 13/20 | 0.69 |
| ▸ | HDAC10 | Q969S8 | 13/20 | 0.69 |
| ▸ | HDAC11 | Q96DB2 | 13/20 | 0.69 |
| ▸ | HDAC8 | Q9BY41 | 13/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.69 |
| ▸ | HDAC9 | Q9UKV0 | 13/20 | 0.69 |
| ▸ | HDAC5 | Q9UQL6 | 13/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5903979 | 0.92 | HDAC1 (0.64) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5903812 | 0.90 | HDAC1 (0.81) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5903824 | 0.85 | HDAC1 (0.65) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5903949 | 0.83 | HDAC1 (0.79) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5904085 | 0.81 | HDAC1 (1.00) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5903954 | 0.75 | HDAC1 (0.79) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5903786 | 0.75 | HDAC1 (0.80) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5903722 | 0.74 | HDAC1 (0.60) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5903919 | 0.74 | HDAC1 (0.57) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5904047 | 0.73 | HDAC1 (0.80) | HDAC1HDAC3HDAC4HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1525199-A1 | SUBSTITUTED THIENYL-HYDROXAMIC ACIDS AS HISTONE DEACETYLASE INHIBITORS | Argenta Discovery Limited (GB) | 2005-04-27 | — | — | EP | disclosed |
| WO-2004013130-A1 | SUBSTITUTED THIENYL-HYDROXAMIC ACIDS AS HISTONE DEACETYLASE INHIBITORS | ARGENTA DISCOVERY LIMITED (GB) | 2004-02-12 | — | — | WO | disclosed |