Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 5/20 | 0.59 |
| ▸ | PARP1 | P09874 | 1/20 | 0.54 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.54 |
| ▸ | CDK4 | P11802 | 1/20 | 0.54 |
| ▸ | CCND1 | P24385 | 1/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.54 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.54 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.54 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CDC25A | P30304 | 1/20 | 0.49 |
| ▸ | CDC25C | P30307 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | DAO | P14920 | 1/20 | 0.49 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5879303 | 0.86 | CHEK1 (0.59) | CHEK1PARP1CCNE2CDK4CCND1 | |
| SCHEMBL5879318 | 0.79 | CHEK1 (0.59) | CHEK1PARP1CCNE2CDK4CCND1 | |
| SCHEMBL5879261 | 0.79 | CHEK1 (0.59) | CHEK1CCNE2CDK4CCND1CCNE1 | |
| SCHEMBL5879256 | 0.79 | CHEK1 (0.63) | CHEK1CCNE2CDK4CCND1CCNE1 | |
| SCHEMBL8874832 | 0.76 | PARP1 (0.75) | CHEK1PARP1LMNACDC25ACDC25C | |
| SCHEMBL5879202 | 0.76 | CDK4 (0.62) | CHEK1CCNE2CDK4CCND1CCNE1 | |
| SCHEMBL7481413 | 0.75 | DAO (0.56) | PARP1CCNE2CDK4CCND1CCNE1 | |
| Bis-Imide A SCHEMBL31061368 | 0.74 | CHEK1 (1.00) | CHEK1PARP1CCNE2CDK4CCND1 | |
| Bis-Imide A SCHEMBL5879127 | 0.74 | CHEK1 (1.00) | CHEK1PARP1CCNE2CDK4CCND1 | |
| SCHEMBL3505546 | 0.73 | CCNE2 (0.48) | CHEK1PARP1CCNE2CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411057-B1 | [3,4-a:3,4-c]carbazole derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2005-04-27 | — | — | EP | disclosed |
| EP-1411057-A1 | [3,4-a:3,4-c]carbazole derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2004-04-21 | — | — | EP | disclosed |