Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGAV | P06756 | 1/20 | 0.35 |
| ▸ | CHKA | P35790 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6097921 | 0.81 | HRH3 (0.40) | HRH3HRH1MCL1HTR2AHTR2C | |
| SCHEMBL6097603 | 0.80 | MAPT (0.41) | HRH3HTR2AHTR2CHTR2BKDM4E | |
| SCHEMBL6099299 | 0.77 | MCL1 (0.43) | HRH3HRH1MCL1HTR2AHTR2C | |
| SCHEMBL6099897 | 0.76 | KDM4E (0.41) | HRH3CYP2D6HTR2AHTR2CHTR2B | |
| SCHEMBL6098861 | 0.76 | HIF1A (0.43) | SLC6A2HTR2AHTR2CHTR2BKDM4E | |
| SCHEMBL6096642 | 0.72 | HRH3 (0.46) | HRH3MCL1 | |
| SCHEMBL6482908 | 0.67 | DRD3 (0.42) | HRH3HRH1SLC6A2SLC6A4DRD3 | |
| SCHEMBL6474621 | 0.66 | DRD3 (0.42) | HTR2ADRD3 | |
| SCHEMBL6358473 | 0.66 | MCL1 (0.43) | CYP2D6SLC6A2SLC6A4MCL1KDM4E | |
| SCHEMBL6474563 | 0.66 | DRD3 (0.45) | DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406902-B1 | HEXAHYDROAZEPINO[4,5-G]INDOLES AND INDOLINES AS 5-HT RECEPTOR LIGANDS | PHARMACIA & UPJOHN CO LLC (US) | 2005-10-19 | — | — | EP | claimed |