Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 20/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL620222 | 1.00 | CHEK1 (0.61) | CHEK1KCNH2CHEK2 | |
| SCHEMBL620421 | 0.93 | CHEK1 (0.64) | CHEK1KCNH2CHEK2 | |
| SCHEMBL620422 | 0.93 | CHEK1 (0.64) | CHEK1KCNH2CHEK2 | |
| SCHEMBL3630753 | 0.93 | CHEK1 (0.64) | CHEK1KCNH2CHEK2 | |
| SCHEMBL620328 | 0.88 | CHEK1 (0.68) | CHEK1KCNH2CHEK2 | |
| SCHEMBL618265 | 0.80 | CHEK1 (0.56) | CHEK1CHEK2 | |
| SCHEMBL30186230 | 0.78 | CHEK1 (0.60) | CHEK1KCNH2CHEK2 | |
| SCHEMBL15391848 | 0.78 | CHEK1 (0.60) | CHEK1KCNH2CHEK2 | |
| SCHEMBL15391847 | 0.78 | CHEK1 (0.60) | CHEK1KCNH2CHEK2 | |
| SCHEMBL15392255 | 0.78 | CHEK1 (0.60) | CHEK1KCNH2CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120040967-A1 | Pyrazin-2-yl-pyridin-2-yl-amine and pyrazin-2-yl-pyrimidin-4-yl-amine Compounds and Their Use | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2012-02-16 | — | — | US | disclosed |
| US-8058045-B2 | Pyrazin-2-yl-pyridin-2-yl-amine and pyrazin-2-yl-pyrimidin-4-yl-amine compounds and their use | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2011-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040967-A1 | Pyrazin-2-yl-pyridin-2-yl-amine and pyrazin-2-yl-pyrimidin-4-yl-amine Compounds and Their Use | CHEK1, CHEK2, PLK1 | CHEK1 1/4885KCNH2 2862/4885CHEK2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.