Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 2/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3562130 | 0.98 | HTR2A (0.47) | HTR2AHIF1ACA1CA2CHEK1 | |
| SCHEMBL23087698 | 0.81 | NPC1 (0.41) | HTR2AHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL4137079 | 0.81 | BRAF (0.42) | HTR2ALMNAMAPTHTR2CAKT1 | |
| SCHEMBL15885278 | 0.80 | CYP2A6 (0.47) | HTR2AHIF1AHTTSMN1; SMN2NPC1 | |
| SCHEMBL5946818 | 0.80 | HTR2A (0.58) | HTR2ASMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL9933261 | 0.79 | HTR2A (0.54) | HTR2APDE2APRMT5WDR77PTGS1 | |
| SCHEMBL3489027 | 0.79 | HTR2A (0.45) | HTR2APDE2APRMT5WDR77HTR2C | |
| SCHEMBL23087650 | 0.79 | HTR2A (0.51) | HTR2ASMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL23087462 | 0.78 | HTR2A (0.46) | HTR2AHIF1ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL27217102 | 0.78 | HTR2A (0.40) | HTR2ACHEK1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509505-A2 | SMALL MOLECULE MODULATORS OF THE 5−HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2005-03-02 | — | — | EP | disclosed |
| WO-2003062206-A2 | SMALL MOLECULE MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2003-07-31 | — | — | WO | disclosed |