Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.53 |
| ▸ | PARP1 | P09874 | 13/20 | 0.50 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.50 |
| ▸ | PARP11 | Q9NR21 | 4/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2265625 | 0.78 | HTR2C (0.47) | HTR2CHTR2BCA12CA9ACHE | |
| SCHEMBL10153320 | 0.72 | HTR2C (0.67) | HTR2CHTR2BCA12CA9ACHE | |
| SCHEMBL15522534 | 0.72 | HTR2C (0.67) | HTR2CHTR2B | |
| SCHEMBL15522686 | 0.72 | MEN1 (0.42) | HTR2CPARP1PARP10PARP11HTR2B | |
| SCHEMBL15415712 | 0.71 | CA12 (0.44) | PARP1PARP10PARP11PDPK1CA12 | |
| SCHEMBL11749876 | 0.70 | CES1 (0.53) | HTR2CHTR2BACHE | |
| SCHEMBL29565246 | 0.70 | CES1 (0.53) | HTR2CHTR2BACHE | |
| SCHEMBL17075196 | 0.69 | PARP1 (0.39) | HTR2CPARP1PARP10PARP11HTR2B | |
| SCHEMBL30542795 | 0.69 | HTR2C (0.50) | HTR2CHTR2BACHE | |
| SCHEMBL6176186 | 0.69 | MAPT (0.38) | HTR2CPARP1PARP10PARP11PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7915280-B2 | Compounds and their uses | EISAI INC. (US) | 2011-03-29 | — | — | US | disclosed |
| US-7915280-B2 | Compounds and their uses | EISAI INC. (US) | 2011-03-29 | — | — | US | disclosed |
| US-RE41150-E1 | Poly(adenosine 5'-diphospho-ribose) polymerase (PARP) inhibitors; compounds based on thieno(4,3,2-ef)(2)benzazepin-6-one | EISAI CORPORATION OF NORTH AMERICA (US) | 2010-02-23 | — | — | US | disclosed |
| US-RE41150-E1 | Poly(adenosine 5'-diphospho-ribose) polymerase (PARP) inhibitors; compounds based on thieno(4,3,2-ef)(2)benzazepin-6-one | EISAI CORPORATION OF NORTH AMERICA (US) | 2010-02-23 | — | — | US | disclosed |
| US-7235557-B2 | Compounds and their uses | MGI GP, INC. (US) | 2007-06-26 | — | — | US | disclosed |
| US-7235557-B2 | Compounds and their uses | MGI GP, INC. (US) | 2007-06-26 | — | — | US | disclosed |
| EP-1208104-B1 | TRICYCLIC INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASES | AGOURON PHARMA (US) | 2005-01-19 | — | — | EP | disclosed |
| US-6548494-B1 | 3,4-dihydro-2H-(1,4)diazepino(6,7,1-hi)indol-1-one or 1-thione derivatives where indole C3 could also be N; use treating cancers as well as stroke, head trauma, and neurodegenerative diseases | AGOURON PHARMACEUTICALS, INC. | 2003-04-15 | — | — | US | disclosed |
| US-3824230-A | 1,2,4,5-TETRAHYDROPYRROLO(3,2,1-JK)(1,4)BENZODIAZEPIN-7(6H)-ONES AND 1,2,4,5-TETRAHYDROPYRROLO(1,2,3-EF)(2,5)BENZODIAZEPIN-6(7H)-ONES | UPJOHN CO | 1974-07-16 | — | — | US | disclosed |