Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.41 |
| ▸ | CCR3 | P51677 | 2/20 | 0.41 |
| ▸ | CYP2A13 | Q16696 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5837289 | 0.87 | CCR3 (0.42) | CCR3CYP2A13KMT2AGAAALDH1A1 | |
| SCHEMBL5867148 | 0.87 | CCR3 (0.56) | CCR3KMT2AALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL6201146 | 0.86 | DRD4 (0.49) | CCR3KMT2AALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL5832033 | 0.85 | CCR3 (0.41) | CXCR4CCR3CYP2A13KMT2AGAA | |
| SCHEMBL5832664 | 0.84 | CCR3 (0.41) | CCR3CYP2A13KMT2AGAAALDH1A1 | |
| SCHEMBL5867206 | 0.83 | DRD4 (0.50) | CCR3CYP2A13KMT2ACYP3A4CYP2D6 | |
| SCHEMBL6201956 | 0.81 | DRD4 (0.49) | CCR3KMT2AALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL5833059 | 0.80 | CCR3 (0.43) | CXCR4CCR3CYP2A13KMT2AGAA | |
| SCHEMBL5832921 | 0.80 | CCR3 (0.42) | CCR3CYP2A13KMT2AGAAALDH1A1 | |
| SCHEMBL5618602 | 0.79 | CCR3 (0.49) | P2RX7CXCR4CCR3CYP2A13KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492537-A1 | MORPHOLINE DERIVATIVES WITH A SUBSTITUTED ACETAMIDE GROUP IN THE 2-POSITION FOR USE AS CCR-3 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2005-01-05 | — | — | EP | disclosed |
| WO-2003082294-A1 | MORPHOLINE DERIVATIVES WITH A SUBSTITUTED ACETAMIDE GROUP IN THE 2-POSITION FOR USE AS CCR-3 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2003-10-09 | — | — | WO | disclosed |