Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 17/20 | 0.60 |
| ▸ | PTPN1 | P18031 | 17/20 | 0.60 |
| ▸ | PTPN5 | P54829 | 17/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | XBP1 | P17861 | 1/20 | 0.58 |
| ▸ | HSPD1 | P10809 | 8/20 | 0.52 |
| ▸ | HSPE1 | P61604 | 8/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6084255 | 0.93 | PTPN2 (0.58) | PTPN2PTPN1PTPN5MAPTKDM4E | |
| SCHEMBL6086151 | 0.88 | PTPN2 (0.63) | PTPN2PTPN1PTPN5HSPD1HSPE1 | |
| SCHEMBL6084787 | 0.87 | PTPN1 (0.44) | PTPN2PTPN1PTPN5HSPD1HSPE1 | |
| SCHEMBL6201863 | 0.86 | PTPN1 (0.74) | PTPN2PTPN1PTPN5MAPTKDM4E | |
| SCHEMBL6085852 | 0.86 | PTPN5 (0.49) | PTPN2PTPN1PTPN5MAPTMEN1 | |
| SCHEMBL6086154 | 0.82 | PTPN5 (0.60) | PTPN2PTPN1PTPN5HSPD1HSPE1 | |
| SCHEMBL6200297 | 0.81 | PTPN1 (0.63) | PTPN2PTPN1PTPN5MAPTKDM4E | |
| SCHEMBL6084264 | 0.81 | PTPN2 (0.66) | PTPN2PTPN1PTPN5MAPTKDM4E | |
| SCHEMBL6086097 | 0.80 | NPC1 (0.52) | MAPTKDM4EALDH1A1MEN1HPGD | |
| SCHEMBL6086007 | 0.79 | AGPAT2 (0.48) | MAPTKDM4EALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377589-B1 | OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2005-09-07 | — | — | EP | claimed |