Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.61 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2100300 | 0.79 | CA12 (0.52) | MAPTMCOLN3CA12CA9TSHR | |
| SCHEMBL3467608 | 0.79 | MAPT (0.63) | MAPTMCOLN3CA12CA9ALDH1A1 | |
| SCHEMBL10285578 | 0.77 | MAPT (0.61) | MAPTMCOLN3CA12CA9ALDH1A1 | |
| SCHEMBL10192055 | 0.76 | MAPT (0.59) | MAPTMCOLN3CA12CA9ALDH1A1 | |
| SCHEMBL2008337 | 0.76 | MAPT (1.00) | MAPTMCOLN3CA12CA9ALDH1A1 | |
| SCHEMBL3467610 | 0.74 | MAPT (0.57) | MAPTMCOLN3CA12CA9ALDH1A1 | |
| SCHEMBL14212101 | 0.74 | MAPT (0.57) | MAPTMCOLN3CA12CA9ALDH1A1 | |
| SCHEMBL10192141 | 0.74 | MAPT (0.57) | MAPTMCOLN3CA12CA9ALDH1A1 | |
| SCHEMBL10192209 | 0.72 | MAPT (0.55) | MAPTMCOLN3CA12CA9ALDH1A1 | |
| SCHEMBL10192213 | 0.71 | MAPT (0.53) | MAPTMCOLN3CA12CA9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |