Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HAT1 | O14929 | 7/20 | 0.49 |
| ▸ | EP300 | Q09472 | 7/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205477 | 0.93 | HDAC3 (0.55) | HDAC3HDAC1HDAC2KMT2AMEN1 | |
| SCHEMBL6275504 | 0.87 | HAT1 (0.54) | HAT1EP300KMT2APOLBMAPT | |
| SCHEMBL6199617 | 0.87 | MAPT (0.53) | HAT1EP300KMT2APOLBMAPT | |
| SCHEMBL6202507 | 0.79 | SMN1; SMN2 (0.48) | HAT1EP300SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL8089030 | 0.77 | SMN1; SMN2 (0.56) | KMT2APOLBMAPTMEN1SMN1; SMN2 | |
| SCHEMBL11349018 | 0.77 | SMN1; SMN2 (0.56) | KMT2APOLBMAPTMEN1SMN1; SMN2 | |
| SCHEMBL12159279 | 0.77 | SMN1; SMN2 (0.56) | KMT2APOLBMAPTMEN1SMN1; SMN2 | |
| SCHEMBL28185251 | 0.76 | SMN1; SMN2 (0.55) | KMT2APOLBMAPTMEN1SMN1; SMN2 | |
| SCHEMBL6219820 | 0.76 | MAPT (0.48) | KMT2APOLBMAPTMEN1NPC1 | |
| SCHEMBL6320430 | 0.76 | NPC1 (0.53) | KMT2APOLBMAPTMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |