SCHEMBL6203449

SCHEMBL6203449

Clc1cccc(Nn2nnc3cncnc32)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 8/20 0.42
CYP2C9 P11712 5/20 0.42
HSD17B10 Q99714 3/20 0.42
CYP3A4 P08684 6/20 0.40
USP2 O75604 5/20 0.40
CYP2C19 P33261 5/20 0.40
TSHR P16473 3/20 0.40
MAPK1 P28482 3/20 0.40
HIF1A Q16665 1/20 0.40
ALOX15 P16050 2/20 0.39
ALDH1A1 P00352 4/20 0.39
MAPT P10636 2/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
KDM4E B2RXH2 1/20 0.39
LMNA P02545 1/20 0.39
GAA P10253 1/20 0.39
HPGD P15428 1/20 0.39
HTT P42858 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28251675 0.78 CYP1A2 (0.42) CYP1A2CYP2C9HSD17B10CYP3A4USP2
Hydrochloric Acid SCHEMBL7659960 0.77 CYP1A2 (0.41) CYP1A2CYP2C9HSD17B10CYP3A4USP2
SCHEMBL10644213 0.68 ADA (0.36) CYP1A2CYP2C9HSD17B10CYP3A4USP2
SCHEMBL8319107 0.66 EGFR (0.60) CYP1A2CYP2C9HSD17B10CYP3A4CYP2C19
SCHEMBL3948301 0.65 CHRNB4 (0.49) MAPTKMT2AGAAEGFRFADS1
Hydrochloric Acid SCHEMBL7659957 0.64 EGFR (0.44) MAPTGAAEGFRFADS1LCK
SCHEMBL3167054 0.63 MEN1 (0.46) HSD17B10TSHRALDH1A1MAPTMEN1
SCHEMBL27968165 0.63 CYP1A2 (0.57) CYP1A2CYP2C9HSD17B10CYP3A4USP2
SCHEMBL28171952 0.62 ADA (0.42) CYP1A2CYP2C9HSD17B10CYP3A4USP2
SCHEMBL31364914 0.60 CCR4 (0.40) CYP1A2USP2TSHRMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1539760-A2 AZAPURINE DERIVATIVES INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) 2005-06-15 EP claimed
WO-2004018473-A2 AZAPURINE DERIVATIVES INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) 2004-03-04 WO claimed