Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 5/20 | 0.60 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.60 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.56 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.56 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.56 |
| ▸ | NOS3 | P29474 | 1/20 | 0.51 |
| ▸ | NOS1 | P29475 | 1/20 | 0.51 |
| ▸ | NOS2 | P35228 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5238675 | 1.00 | CHRNB4 (0.60) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1 | |
| SCHEMBL6203979 | 0.81 | CHRNB4 (0.57) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1 | |
| SCHEMBL5238160 | 0.81 | CHRNB4 (0.57) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1 | |
| SCHEMBL23638221 | 0.78 | CHRNB4 (0.54) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1 | |
| SCHEMBL9245004 | 0.75 | CHRNB4 (0.64) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1 | |
| SCHEMBL12232966 | 0.75 | CHRNB4 (0.68) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1 | |
| SCHEMBL9245008 | 0.75 | CHRNB4 (0.64) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1 | |
| SCHEMBL1928412 | 0.74 | CHRNB4 (0.72) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1 | |
| SCHEMBL1928695 | 0.74 | CHRNB4 (0.72) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1 | |
| Hydrochloric Acid SCHEMBL9241706 | 0.74 | CHRNB4 (0.63) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1507776-A1 | 2-OXO-1,3,4-TRIHYDROQUINAZOLINYL DERIVATIVES FOR THE TREATMENT OF CELL PROLIFERATION-RELATED DISORDERS | Amgen Inc. (US) | 2005-02-23 | — | — | EP | disclosed |
| WO-2003101985-A1 | 2-OXO-1,3,4-TRIHYDROQUINAZOLINYL DERIVATIVES FOR THE TREATMENT OF CELL PROLIFERATION-RELATED DISORDERS | AMGEN INC. (US) | 2003-12-11 | — | — | WO | disclosed |