Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL646838 | 1.00 | DPP4 (0.40) | DPP4CTSSCTSKDPP8BTK | |
| SCHEMBL648653 | 0.99 | DPP4 (0.39) | DPP4CTSSCTSKDPP8BTK | |
| SCHEMBL648669 | 0.90 | DPP4 (0.42) | DPP4CTSSCTSKDPP8BTK | |
| SCHEMBL647255 | 0.89 | DPP4 (0.41) | DPP4CTSSCTSKDPP8BTK | |
| SCHEMBL645764 | 0.85 | DPP4 (0.58) | DPP4CTSSCTSKDPP8AAK1 | |
| SCHEMBL6205677 | 0.84 | DPP4 (0.57) | DPP4CTSSCTSKDPP8AAK1 | |
| SCHEMBL648248 | 0.84 | DPP4 (0.57) | DPP4CTSSCTSKDPP8AAK1 | |
| SCHEMBL648249 | 0.84 | DPP4 (0.57) | DPP4CTSSCTSKDPP8AAK1 | |
| SCHEMBL6205055 | 0.84 | DPP4 (0.57) | DPP4CTSSCTSKDPP8AAK1 | |
| SCHEMBL3596637 | 0.84 | AAK1 (0.36) | DPP4CTSSCTSKBTKAAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1560811-A2 | PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) | Abbott Laboratories (US) | 2005-08-10 | — | — | EP | disclosed |
| WO-2004026822-A2 | PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) | ABBOTT LABORATORIES (US) | 2004-04-01 | — | — | WO | disclosed |