Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 19/20 | 0.73 |
| ▸ | BTK | Q06187 | 2/20 | 0.67 |
| ▸ | ABL1 | P00519 | 1/20 | 0.64 |
| ▸ | EGFR | P00533 | 1/20 | 0.64 |
| ▸ | PRKCB | P05771 | 1/20 | 0.64 |
| ▸ | INSR | P06213 | 1/20 | 0.64 |
| ▸ | LCK | P06239 | 1/20 | 0.64 |
| ▸ | FYN | P06241 | 1/20 | 0.64 |
| ▸ | LYN | P07948 | 1/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.64 |
| ▸ | SRC | P12931 | 1/20 | 0.64 |
| ▸ | PRKCA | P17252 | 1/20 | 0.64 |
| ▸ | FLT1 | P17948 | 1/20 | 0.64 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.64 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.64 |
| ▸ | AKT1 | P31749 | 1/20 | 0.64 |
| ▸ | FLT4 | P35916 | 1/20 | 0.64 |
| ▸ | KDR | P35968 | 1/20 | 0.64 |
| ▸ | FLT3 | P36888 | 1/20 | 0.64 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6202976 | 0.91 | EPHB4 (0.84) | EPHB4BTKABL1EGFRPRKCB | |
| SCHEMBL4811120 | 0.87 | SYK (0.79) | EPHB4BTKABL1EGFRPRKCB | |
| SCHEMBL4806254 | 0.83 | SYK (0.85) | EPHB4BTKSYK | |
| SCHEMBL4803219 | 0.82 | BTK (0.85) | EPHB4BTKSYK | |
| SCHEMBL6204144 | 0.82 | EPHB4 (0.92) | EPHB4 | |
| SCHEMBL6220156 | 0.81 | EPHB4 (0.73) | EPHB4BTKABL1EGFRPRKCB | |
| SCHEMBL5477799 | 0.81 | BTK (0.61) | EPHB4BTKSYK | |
| SCHEMBL5486801 | 0.80 | EPHB4 (1.00) | EPHB4BTKABL1EGFRPRKCB | |
| SCHEMBL5486306 | 0.80 | EPHB4 (1.00) | EPHB4BTKABL1EGFRPRKCB | |
| SCHEMBL5478193 | 0.80 | EPHB4 (0.67) | EPHB4BTKKDRSYKTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100537571-C | Imidazo[1,2-a]pyrazin-8-ylamines, method of making and method of use thereof | CELLULAR GENOMICS INC (US) | 2009-09-09 | — | — | CN | disclosed |
| US-20050288295-A1 | Certain imidazo[1,2-a]pyrazin-8-ylamines, method of making, and method of use thereof | CGI PHARMACEUTICALS, INC. | 2005-12-29 | — | — | US | disclosed |
| CN-1668619-A | Imidazo [1, 2-a ] pyrazin-8-ylamines, methods of making and methods of use thereof | CELLULAR GENOMICS INC (US) | 2005-09-14 | — | — | CN | disclosed |
| US-6919340-B2 | Imidazo[1,2-a]pyrazin-8-ylamines, method of making, and method of use thereof | CELLULAR GENOMICS, INC. (US) | 2005-07-19 | — | — | US | disclosed |
| EP-1509526-A2 | IMIDAZO(1,2-A)PYRAZIN-8-YLAMINES, METHOD OF MAKING, AND METHOD OF USE THEREOF | Cellular Genomics Inc. (US) | 2005-03-02 | — | — | EP | disclosed |
| US-20030212073-A1 | Imidazo[1,2-a]pyrazin-8-ylamines, method of making, and method of use thereof | GILEAD CONNECTICUT, INC. | 2003-11-13 | — | — | US | disclosed |
| WO-2003089434-A2 | IMIDAZO[1,2-a]PYRAZIN-8-YLAMINES METHOD OF MAKING AND METHOD OF USE THEREOF | CELLULAR GENOMICS, INC. (US) | 2003-10-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030212073-A1 | Imidazo[1,2-a]pyrazin-8-ylamines, method of making, and method of use thereof | PRKACA, MAP3K8, MAP3K1 | EPHB4 4069/4885BTK 715/4885ABL1 82/4885 |
| US-20050288295-A1 | Certain imidazo[1,2-a]pyrazin-8-ylamines, method of making, and method of use thereof | MAP3K8, MAP3K1, PRKACA | EPHB4 4328/4885BTK 477/4885ABL1 192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.