Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.36 |
| ▸ | ACHE | P22303 | 6/20 | 0.36 |
| ▸ | BCHE | P06276 | 5/20 | 0.36 |
| ▸ | CCR1 | P32246 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3439349 | 0.79 | CCR1 (0.39) | RAB9ACCR1CYP3A4MEN1KMT2A | |
| SCHEMBL10284897 | 0.76 | CHRNA7 (0.40) | PTGS2CCR1CYP3A4KMT2AHRH4 | |
| SCHEMBL15290565 | 0.76 | CCR1 (0.40) | CCR1CYP3A4HRH4 | |
| SCHEMBL3439409 | 0.76 | CCR1 (0.38) | CCR1CYP3A4HRH4 | |
| SCHEMBL3465973 | 0.76 | CCR1 (0.38) | CCR1CYP3A4HRH4 | |
| Hydrochloric Acid SCHEMBL27827247 | 0.75 | CCR1 (0.37) | CCR1CYP3A4HRH4 | |
| Hydrochloric Acid SCHEMBL567868 | 0.75 | CCR1 (0.37) | CCR1CYP3A4HRH4 | |
| SCHEMBL3465322 | 0.74 | CCR1 (0.39) | CCR1CYP3A4HRH4 | |
| SCHEMBL3465451 | 0.74 | CCR1 (0.39) | CCR1CYP3A4HRH4 | |
| SCHEMBL3465541 | 0.74 | CCR1 (0.39) | CCR1CYP3A4HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551841-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |