Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5226516 | 0.90 | NAMPT (0.47) | NAMPTPOLBKDM4EPKMCCR8 | |
| SCHEMBL6202001 | 0.83 | HDAC2 (0.54) | HDAC1HDAC3HDAC2 | |
| SCHEMBL5224407 | 0.81 | HDAC2 (0.47) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL6528319 | 0.79 | HDAC1 (0.63) | HDAC1NAMPTHDAC3HDAC2HDAC4 | |
| SCHEMBL8292235 | 0.76 | HDAC1 (0.58) | HDAC1HDAC3HDAC2 | |
| SCHEMBL6206105 | 0.75 | NAMPT (0.40) | HDAC1NAMPTACKR3 | |
| SCHEMBL5226822 | 0.74 | MAPK8 (0.46) | HDAC1NAMPTHDAC3HDAC2HDAC8 | |
| SCHEMBL2830416 | 0.73 | NAMPT (0.59) | HDAC1NAMPTHDAC3HDAC2HDAC4 | |
| SCHEMBL6204132 | 0.72 | HDAC2 (0.60) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL14447471 | 0.72 | PTPN2 (0.62) | HDAC1NAMPTHDAC3HDAC2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501508-A1 | INHIBITORS OF HISTONE DEACETYLASE | Astrazeneca AB (SE) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003092686-A1 | INHIBITORS OF HISTONE DEACETYLASE | ASTRAZENECA AB (SE) | 2003-11-13 | — | — | WO | disclosed |