Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 20/20 | 0.72 |
| ▸ | RAF1 | P04049 | 6/20 | 0.71 |
| ▸ | KDR | P35968 | 7/20 | 0.62 |
| ▸ | LCK | P06239 | 5/20 | 0.61 |
| ▸ | FYN | P06241 | 5/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.61 |
| ▸ | KIT | P10721 | 5/20 | 0.61 |
| ▸ | FLT1 | P17948 | 5/20 | 0.61 |
| ▸ | FLT4 | P35916 | 5/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.61 |
| ▸ | SRC | P12931 | 2/20 | 0.60 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.56 |
| ▸ | STK25 | O00506 | 1/20 | 0.56 |
| ▸ | CIT | O14578 | 1/20 | 0.56 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.56 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.56 |
| ▸ | PAK3 | O75914 | 1/20 | 0.56 |
| ▸ | STK10 | O94804 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13788619 | 0.88 | BRAF (0.73) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL4323637 | 0.84 | BRAF (1.00) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL13211389 | 0.83 | BRAF (0.73) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL6701429 | 0.83 | BRAF (0.69) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL2889336 | 0.83 | BRAF (0.70) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL6701432 | 0.83 | BRAF (0.69) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL13559539 | 0.83 | BRAF (0.69) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL2887083 | 0.83 | BRAF (1.00) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL2886149 | 0.82 | BRAF (0.75) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL13211229 | 0.82 | BRAF (0.72) | BRAFRAF1KDRLCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499311-A1 | SUBSTITUTED BENZAZOLES AND USE THEREOF AS RAF KINASE INHIBITORS | Chiron Corporation (US) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003082272-A1 | SUBSTITUTED BENZAZOLES AND USE THEREOF AS RAF KINASE INHIBITORS | CHIRON CORPORATION (US) | 2003-10-09 | — | — | WO | disclosed |