Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 1/20 | 0.51 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.44 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28755744 | 0.84 | PARP1 (0.54) | HSD17B10PTGS1PTGS2MAPTSMN1; SMN2 | |
| SCHEMBL10416036 | 0.84 | ANPEP (0.53) | ANPEPENPEPHPGDHSD17B10CYP1A2 | |
| SCHEMBL6204470 | 0.82 | ANPEP (0.51) | ANPEPENPEPHPGDHSD17B10CYP1A2 | |
| SCHEMBL15020131 | 0.82 | ANPEP (0.51) | ANPEPENPEPHPGDHSD17B10CYP1A2 | |
| SCHEMBL30354039 | 0.81 | ANPEP (0.58) | ANPEPENPEPHPGDHSD17B10CYP1A2 | |
| SCHEMBL371525 | 0.81 | ANPEP (0.58) | ANPEPENPEPHPGDHSD17B10CYP1A2 | |
| SCHEMBL10653124 | 0.81 | ANPEP (0.50) | ANPEPENPEPHPGDHSD17B10CYP1A2 | |
| Isophthalic Acid SCHEMBL25190289 | 0.79 | ANPEP (0.56) | ANPEPENPEPHPGDHSD17B10CYP1A2 | |
| SCHEMBL14843614 | 0.79 | ANPEP (0.56) | ANPEPENPEPHPGDHSD17B10CYP1A2 | |
| SCHEMBL27485681 | 0.78 | ANPEP (0.51) | ANPEPENPEPHPGDHSD17B10CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1668601-A | N-substituted tricyclic 3-aminopyrazoles as PDFG receptor inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2005-09-14 | — | — | CN | disclosed |
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |