Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | XDH | P47989 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205563 | 0.80 | KMT2A (1.00) | KMT2AKDM4EMEN1MAPTXDH | |
| SCHEMBL6205834 | 0.80 | KMT2A (0.66) | KMT2AKDM4EMEN1MAPTXDH | |
| SCHEMBL12795372 | 0.79 | KMT2A (0.74) | KMT2AKDM4EMEN1MAPTXDH | |
| SCHEMBL10618063 | 0.78 | KMT2A (0.44) | KMT2AKDM4EMEN1MAPTXDH | |
| SCHEMBL30120645 | 0.77 | KMT2A (0.71) | KMT2AKDM4EMEN1MAPTXDH | |
| SCHEMBL544885 | 0.77 | KMT2A (0.71) | KMT2AKDM4EMEN1MAPTXDH | |
| SCHEMBL1143393 | 0.77 | KMT2A (0.70) | KMT2AKDM4EMEN1MAPTXDH | |
| SCHEMBL3804511 | 0.77 | KMT2A (0.70) | KMT2AKDM4EMEN1MAPTXDH | |
| SCHEMBL1457049 | 0.77 | KMT2A (0.70) | KMT2AKDM4EMEN1MAPTXDH | |
| SCHEMBL60939 | 0.76 | KMT2A (0.71) | KMT2AKDM4EMEN1MAPTXDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551841-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |