Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 3/20 | 0.41 |
| ▸ | CCR5 | P51681 | 11/20 | 0.41 |
| ▸ | CCR2 | P41597 | 2/20 | 0.39 |
| ▸ | CCR7 | P32248 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | RARA | P10276 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.37 |
| ▸ | CCR4 | P51679 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205525 | 1.00 | RARB (0.41) | RARBCCR5CCR2CCR7KCNH2 | |
| SCHEMBL6204657 | 0.91 | RARB (0.48) | RARBCCR5CCR2CCR7RARA | |
| SCHEMBL6204659 | 0.91 | RARB (0.48) | RARBCCR5CCR2CCR7RARA | |
| SCHEMBL5940268 | 0.88 | RARB (0.44) | RARBCCR5CCR2CCR7KCNH2 | |
| SCHEMBL5940270 | 0.88 | RARB (0.44) | RARBCCR5CCR2CCR7KCNH2 | |
| SCHEMBL5940260 | 0.87 | RARB (0.44) | RARBCCR5CCR2CCR7KCNH2 | |
| SCHEMBL5940257 | 0.87 | RARB (0.44) | RARBCCR5CCR2CCR7KCNH2 | |
| SCHEMBL5940261 | 0.85 | RARB (0.44) | RARBCCR5CCR2CCR7KCNH2 | |
| SCHEMBL3459772 | 0.83 | RARB (0.45) | RARBCCR5CCR2CCR7KCNH2 | |
| SCHEMBL3459770 | 0.83 | RARB (0.45) | RARBCCR5CCR2CCR7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1593681-A1 | TRICYCLIC COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE | Takeda Pharmaceutical Company Limited (JP) | 2005-11-09 | — | — | EP | disclosed |