Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 3/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.61 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MMP1 | P03956 | 5/20 | 0.56 |
| ▸ | MMP2 | P08253 | 5/20 | 0.56 |
| ▸ | MMP9 | P14780 | 5/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4029206 | 0.85 | HDAC2 (0.76) | HDAC2HDAC3HDAC4HDAC1HDAC8 | |
| SCHEMBL29060766 | 0.85 | HDAC2 (0.76) | HDAC2HDAC3HDAC4HDAC1HDAC8 | |
| SCHEMBL28440927 | 0.83 | HDAC2 (0.73) | HDAC2HDAC3HDAC4HDAC1HDAC8 | |
| SCHEMBL28440928 | 0.83 | HDAC2 (0.73) | HDAC2HDAC3HDAC4HDAC1HDAC8 | |
| SCHEMBL7656834 | 0.80 | HDAC2 (0.63) | HDAC2HDAC3HDAC4HDAC1HDAC8 | |
| SCHEMBL25510259 | 0.79 | KMT2A (0.73) | HDAC2HDAC3HDAC4HDAC1HDAC8 | |
| SCHEMBL9782051 | 0.78 | HDAC2 (0.66) | HDAC2HDAC3HDAC4HDAC1HDAC8 | |
| SCHEMBL6643474 | 0.78 | HDAC3 (0.66) | HDAC2HDAC3HDAC4HDAC1HDAC8 | |
| SCHEMBL9782058 | 0.78 | HDAC2 (0.66) | HDAC2HDAC3HDAC4HDAC1HDAC8 | |
| SCHEMBL6829701 | 0.78 | HTT (0.74) | HDAC2HDAC3HDAC4HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532128-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002977-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-01-08 | — | — | WO | disclosed |
| US-4310517-A | Tumor-resolving and histolytic medicaments and their use | TROPONWERKE GMBH & CO., KG (DE) | 1982-01-12 | — | — | US | disclosed |