Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 5/20 | 0.37 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.37 |
| ▸ | KDR | P35968 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 5/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 5/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 2/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.32 |
| ▸ | TUBB | P07437 | 2/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.32 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.32 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.32 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.32 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.32 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.32 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6399433 | 0.91 | MAP2K1 (0.37) | MAP2K1MAP2K2KDRCYP3A4PDCD1 | |
| SCHEMBL6398977 | 0.90 | KDR (0.34) | MAP2K1MAP2K2KDRCHRNA7KCNH2 | |
| SCHEMBL6207867 | 0.89 | CHRNA7 (0.33) | MAP2K1MAP2K2KDRCYP3A4CHRNA7 | |
| SCHEMBL6207302 | 0.88 | PDCD1 (0.39) | MAP2K1MAP2K2KDRCYP3A4PDCD1 | |
| SCHEMBL6207184 | 0.87 | FLT1 (0.39) | KDRFLT1 | |
| SCHEMBL6191149 | 0.87 | MAP2K1 (0.35) | MAP2K1MAP2K2KDRADCY1RXFP1 | |
| SCHEMBL6186912 | 0.87 | MAP2K1 (0.35) | MAP2K1MAP2K2KDRADCY1RXFP1 | |
| SCHEMBL6230975 | 0.87 | CHRNA7 (0.34) | KDRCYP3A4CHRNA7KCNH2FLT1 | |
| SCHEMBL6187962 | 0.86 | CHRNA7 (0.34) | MAP2K1MAP2K2CYP3A4CHRNA7KCNH2 | |
| SCHEMBL6208327 | 0.86 | MAP2K1 (0.52) | MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004186-A1 | MEK inhibiting compounds | PFIZER INC | 2005-01-06 | — | — | US | claimed |
| EP-1578736-A1 | MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL-PHENYLAMINE DERIVATIVES | Warner-Lambert Company LLC (US) | 2005-09-28 | — | — | EP | disclosed |
| US-20050004186-A1 | MEK inhibiting compounds | PFIZER INC | 2005-01-06 | — | — | US | disclosed |
| WO-2004056789-A1 | MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL PHENYLAMINE DERIVATES | WARNER-LAMBERT COMPANY LLC (US) | 2004-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004186-A1 | MEK inhibiting compounds | MAPK1, MAP3K1, MAPK3 | MAP2K1 46/4885MAP2K2 40/4885KDR 202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.