Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 10/20 | 0.43 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205880 | 1.00 | BACE1 (0.43) | BACE1SLC6A11BCHECTSD | |
| SCHEMBL5379155 | 0.80 | F2 (0.42) | BCHE | |
| SCHEMBL5379400 | 0.79 | KLK5 (0.54) | — | |
| SCHEMBL5379391 | 0.79 | KLK5 (0.54) | — | |
| SCHEMBL5379396 | 0.79 | KLK5 (0.54) | — | |
| SCHEMBL2841652 | 0.79 | BACE1 (0.52) | BACE1SLC6A11BCHE | |
| SCHEMBL8578649 | 0.79 | BACE1 (0.52) | BACE1SLC6A11BCHE | |
| Hydrochloric Acid SCHEMBL5219159 | 0.79 | F2 (0.41) | BCHE | |
| SCHEMBL5930039 | 0.77 | BACE1 (0.53) | BACE1SLC6A11BCHECTSD | |
| SCHEMBL5930046 | 0.77 | BACE1 (0.53) | BACE1SLC6A11BCHECTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-A1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LIMITED (GB) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004050619-A1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LIMITED (GB) | 2004-06-17 | — | — | WO | disclosed |