Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 14/20 | 0.57 |
| ▸ | HTR2C | P28335 | 13/20 | 0.57 |
| ▸ | HTR2B | P41595 | 13/20 | 0.57 |
| ▸ | DRD1 | P21728 | 3/20 | 0.40 |
| ▸ | DRD5 | P21918 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1E | P28566 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1902950 | 0.84 | HTR2C (0.80) | HTR2AHTR2CHTR2B | |
| SCHEMBL1095615 | 0.84 | HTR2C (0.80) | HTR2AHTR2CHTR2B | |
| SCHEMBL1095614 | 0.84 | HTR2C (0.80) | HTR2AHTR2CHTR2B | |
| SCHEMBL1095283 | 0.73 | HTR2C (1.00) | HTR2AHTR2CHTR2BHTR1AHTR1D | |
| SCHEMBL1095284 | 0.73 | HTR2C (1.00) | HTR2AHTR2CHTR2BHTR1AHTR1D | |
| SCHEMBL1907657 | 0.73 | HTR2C (1.00) | HTR2AHTR2CHTR2BHTR1AHTR1D | |
| SCHEMBL9290580 | 0.72 | HTR2C (0.82) | HTR2AHTR2CHTR2B | |
| SCHEMBL14607586 | 0.72 | HTR2C (0.69) | HTR2AHTR2CHTR2BDRD1DRD5 | |
| SCHEMBL1105042 | 0.71 | HTR2C (0.72) | HTR2AHTR2CHTR2BDRD1DRD5 | |
| SCHEMBL1095159 | 0.71 | HTR2C (0.72) | HTR2AHTR2CHTR2BDRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1557409-A1 | 5HT2C receptor modulators | Arena Pharmaceuticals, Inc. (US) | 2005-07-27 | — | — | EP | disclosed |