SCHEMBL6206380

SCHEMBL6206380

CCCc1cc(CCC)c2onc(C(F)(F)F)c2c1OC(c1ccc(CC)cc1)c1nnn[nH]1

nearest known ligand 0.42

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 14/20 0.42
PPARG P37231 13/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4013379 0.87 PPARA (0.55) PPARAPPARG
SCHEMBL4010340 0.81 PPARA (0.65) PPARAPPARG
SCHEMBL4017608 0.80 PPARA (0.55) PPARAPPARG
SCHEMBL4012672 0.79 PPARA (0.65) PPARAPPARG
SCHEMBL4012839 0.79 PPARA (0.66) PPARAPPARG
SCHEMBL4013902 0.78 PPARA (0.66) PPARAPPARG
SCHEMBL6205683 0.78 PPARG (0.37) PPARAPPARG
SCHEMBL6112145 0.67 PPARA (0.44) PPARAPPARG
SCHEMBL4013188 0.67 PPARG (0.49) PPARAPPARG
SCHEMBL6100733 0.66 PPARA (0.62) PPARAPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1366012-A4 2-ARYLOXY-2-ARYLALKANOIC ACIDS FOR DIABETES AND LIPID DISORDERS MERCK & CO INC (US) 2005-11-02 EP disclosed
EP-1366012-A2 2-ARYLOXY-2-ARYLALKANOIC ACIDS FOR DIABETES AND LIPID DISORDERS Merck & Co., Inc. (US) 2003-12-03 EP disclosed
WO-2002064094-A2 2-ARYLOXY-2-ARYLALKANOIC ACIDS FOR DIABETES AND LIPID DISORDERS MERCK & CO., INC. (US) 2002-08-22 WO disclosed