Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205594 | 0.90 | POLB (0.82) | POLBKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL6205315 | 0.88 | POLB (0.70) | POLBKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL6206611 | 0.88 | POLB (0.73) | POLBKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL6232306 | 0.88 | POLB (0.75) | POLBKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL6227980 | 0.88 | KDM4E (0.73) | POLBKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL6203893 | 0.88 | POLB (0.72) | POLBKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL6205957 | 0.87 | POLB (0.64) | POLBKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL6205316 | 0.87 | POLB (0.68) | POLBKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL6205266 | 0.87 | POLB (0.70) | POLBKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL6203683 | 0.87 | POLB (0.63) | POLBKDM4EMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177177-B1 | SUBSTITUTED 4-OXO-QUINOLINE-3-CARBOXAMIDES: GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORP (US) | 2005-02-23 | — | — | EP | claimed |
| US-6413956-B1 | AGONISTS, ANTAGONISTS OR INVERSE AGONISTS AND LOCALIZATION PROBES FOR GAMMA AMINOBUTYRIC ACID BRAIN RECEPTORS; ANXIETY, DEPRESSION, DOWN SYNDROME, SLEEP AND SEIZURE DISORDERS, OVERDOSE WITH BENZODIAZEPINE DRUGS AND MEMORY ENHANCEMENT | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | claimed |