Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1749339 | 0.97 | MAPT (0.53) | MAPTALDH1A1MAPK1LMNASMN1; SMN2 | |
| SCHEMBL1749338 | 0.97 | MAPT (0.53) | MAPTALDH1A1MAPK1LMNASMN1; SMN2 | |
| SCHEMBL1750106 | 0.89 | MAPT (0.53) | MAPTALDH1A1MAPK1LMNASMN1; SMN2 | |
| SCHEMBL1750104 | 0.89 | MAPT (0.53) | MAPTALDH1A1MAPK1LMNASMN1; SMN2 | |
| SCHEMBL1749240 | 0.82 | GFER (0.40) | MAPTALDH1A1MAPK1LMNASMN1; SMN2 | |
| SCHEMBL1749237 | 0.82 | GFER (0.40) | MAPTALDH1A1MAPK1LMNASMN1; SMN2 | |
| SCHEMBL4351231 | 0.81 | MAPT (0.57) | MAPTALDH1A1MAPK1LMNASMN1; SMN2 | |
| SCHEMBL2636121 | 0.80 | MCHR1 (0.45) | CCR5MCHR1 | |
| SCHEMBL1749521 | 0.77 | MCHR1 (0.54) | MAPTALDH1A1MAPK1LMNASMN1; SMN2 | |
| SCHEMBL1748971 | 0.77 | MCHR1 (0.54) | MAPTALDH1A1MAPK1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1597228-A2 | SUBSTITUTED N-ARYLHETEROCYCLES, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENTS | Sanofi-Aventis Deutschland GmbH (DE) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004072025-A2 | SUBSTITUTED N-ARYLHETEROCYCLES, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-08-26 | — | — | WO | disclosed |