SCHEMBL620659

SCHEMBL620659

O=CCc1nc2ccccc2s1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
UBE2T Q9NPD8 1/20 0.59
ASIC3 Q9UHC3 1/20 0.59
SMN1; SMN2 Q16637 6/20 0.53
RAB9A P51151 5/20 0.53
NPC1 O15118 5/20 0.53
L3MBTL1 Q9Y468 2/20 0.51
MAPK1 P28482 1/20 0.51
CYP1A2 P05177 2/20 0.51
CYP2C19 P33261 2/20 0.51
ALOX15 P16050 1/20 0.51
HTT P42858 1/20 0.51
HPGD P15428 4/20 0.50
KMT2A Q03164 4/20 0.50
MEN1 O00255 2/20 0.50
ALDH1A1 P00352 1/20 0.50
MAPT P10636 4/20 0.49
PDE10A Q9Y233 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2C9 P11712 1/20 0.47
TSHR P16473 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31595800 0.82 SMN1; SMN2 (0.56) UBE2TASIC3SMN1; SMN2RAB9ANPC1
SCHEMBL6510681 0.82 SMN1; SMN2 (0.56) UBE2TASIC3SMN1; SMN2RAB9ANPC1
SCHEMBL3424669 0.81 UBE2T (0.59) UBE2TASIC3SMN1; SMN2RAB9ANPC1
SCHEMBL1077024 0.81 UBE2T (0.59) UBE2TASIC3SMN1; SMN2RAB9ANPC1
Fluoride SCHEMBL2461456 0.80 UBE2T (0.58) UBE2TASIC3SMN1; SMN2RAB9ANPC1
SCHEMBL31596110 0.80 SMN1; SMN2 (0.61) UBE2TASIC3SMN1; SMN2RAB9ANPC1
SCHEMBL14960023 0.80 SMN1; SMN2 (0.61) UBE2TASIC3SMN1; SMN2RAB9ANPC1
SCHEMBL6001358 0.79 UBE2T (0.56) UBE2TASIC3SMN1; SMN2RAB9ANPC1
SCHEMBL6013468 0.79 UBE2T (0.56) UBE2TASIC3SMN1; SMN2RAB9ANPC1
SCHEMBL9698399 0.79 UBE2T (0.61) UBE2TASIC3SMN1; SMN2RAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2603496-A1 1,4,5,6-TETRAHYDRO-PYRIMIDIN-2-YLAMINE COMPOUNDS F.HOFFMANN-LA ROCHE AG (CH) 2013-06-19 EP disclosed
WO-2012019966-A1 1,4,5,6-TETRAHYDRO-PYRIMIDIN-2-YLAMINE COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2012-02-16 WO disclosed
EP-1605946-A2 THIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES Vertex Pharmaceuticals Incorporated (US) 2005-12-21 EP disclosed
WO-2004087699-A2 THIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES VERTEX PHARMACEUTICALS INCORPORATED (US) 2004-10-14 WO disclosed