SCHEMBL6206620

SCHEMBL6206620

CCC(N)C(=O)c1noc(-c2ccccc2)n1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 4/20 0.55
HDAC1 Q13547 3/20 0.55
HDAC8 Q9BY41 2/20 0.55
NOTUM Q6P988 1/20 0.44
ALDH1A1 P00352 2/20 0.43
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
KDM4E B2RXH2 1/20 0.43
MAPT P10636 1/20 0.43
PKM P14618 1/20 0.43
HPGD P15428 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
HSD17B10 Q99714 1/20 0.43
TPH1 P17752 6/20 0.43
NR1H4 Q96RI1 2/20 0.42
KMT2A Q03164 1/20 0.41
SMPD1 P17405 1/20 0.40
NFKB1 P19838 1/20 0.40
NFKB2 Q00653 1/20 0.40
RELA Q04206 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5954867 1.00 HDAC6 (0.55) HDAC6HDAC1HDAC8NOTUMALDH1A1
SCHEMBL5524548 0.81 HDAC6 (0.49) HDAC6HDAC1HDAC8NOTUMALDH1A1
SCHEMBL5524543 0.81 HDAC6 (0.49) HDAC6HDAC1HDAC8NOTUMALDH1A1
SCHEMBL8225582 0.80 HDAC6 (0.48) HDAC6HDAC1HDAC8NOTUMALDH1A1
SCHEMBL14427046 0.79 HDAC6 (0.53) HDAC6HDAC1HDAC8NOTUMALDH1A1
SCHEMBL14389891 0.78 HDAC6 (0.62) HDAC6HDAC1HDAC8NOTUMALDH1A1
SCHEMBL3870371 0.78 HDAC1 (0.44) HDAC6HDAC1HDAC8NOTUMALDH1A1
SCHEMBL14959517 0.76 HDAC6 (0.68) HDAC6HDAC1HDAC8NOTUMALDH1A1
SCHEMBL18606702 0.76 HDAC1 (0.68) HDAC6HDAC1HDAC8NOTUMALDH1A1
SCHEMBL28784675 0.75 HDAC6 (0.72) HDAC6HDAC1HDAC8NOTUMALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1515726-A1 MORPHOLINE AND TETRAHYDROPYRAN DERIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS Aventis Pharmaceuticals, Inc. (US) 2005-03-23 EP claimed
WO-2004002491-A1 MORPHOLINE AND TETRAHYDROPYRAN DRIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS AVENTIS PHARMACEUTICALS INC. (US) 2004-01-08 WO claimed
EP-1515726-A1 MORPHOLINE AND TETRAHYDROPYRAN DERIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS Aventis Pharmaceuticals, Inc. (US) 2005-03-23 EP disclosed
WO-2004002491-A1 MORPHOLINE AND TETRAHYDROPYRAN DRIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS AVENTIS PHARMACEUTICALS INC. (US) 2004-01-08 WO disclosed