SCHEMBL6206631

SCHEMBL6206631

CCOC(=O)c1cc(OCc2ccccc2)c2ccc(OC)cc2c1

nearest known ligand 0.60

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.51
MEN1 O00255 1/20 0.49
HSP90AA1 P07900 1/20 0.49
KMT2A Q03164 1/20 0.49
MTNR1A P48039 3/20 0.48
HDAC8 Q9BY41 1/20 0.47
P2RY14 Q15391 1/20 0.47
HPGD P15428 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
NPC1 O15118 1/20 0.47
RAB9A P51151 1/20 0.47
MTNR1B P49286 2/20 0.47
KDM4E B2RXH2 1/20 0.45
ALDH1A1 P00352 1/20 0.45
LMNA P02545 1/20 0.45
MAPT P10636 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
MRGPRX4 Q96LA9 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25721332 0.90 HPGD (0.54) MTNR1AHDAC8P2RY14HPGDSMN1; SMN2
SCHEMBL13379254 0.87 MAOB (0.47) MAOBMEN1HSP90AA1KMT2AHPGD
SCHEMBL6204953 0.87 P2RY14 (0.61) MEN1KMT2AMTNR1AHDAC8P2RY14
SCHEMBL2809626 0.86 MRGPRX4 (0.51) MAOBMEN1HSP90AA1KMT2AHPGD
SCHEMBL8180897 0.85 PPIA (0.44) MEN1HSP90AA1KMT2AHDAC8HPGD
SCHEMBL13057641 0.83 MEN1 (0.57) MAOBMEN1HSP90AA1KMT2AP2RY14
SCHEMBL8133701 0.83 MRGPRX4 (0.49) MAOBMEN1HSP90AA1KMT2AHPGD
SCHEMBL2931013 0.82 MEN1 (0.56) MAOBMEN1HSP90AA1KMT2AP2RY14
SCHEMBL2931528 0.81 MEN1 (0.48) MAOBMEN1HSP90AA1KMT2AP2RY14
SCHEMBL2929211 0.80 MEN1 (0.48) MAOBMEN1HSP90AA1KMT2AP2RY14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0888301-B1 MCBI ANALOGS OF CC-1065 AND THE DUOCARMYCINS SCRIPPS RESEARCH INST (US) 2005-08-10 EP disclosed
EP-0888301-A4 MCBI ANALOGS OF CC-1065 AND THE DUOCARMYCINS SCRIPPS RESEARCH INST (US) 2002-05-08 EP disclosed
US-5985908-A MCBI (7-METHOXY-1,2,9A-TETRA-HYDROCYCLOPROPA(C)BENZ(E)INDOL-4-ONE) IS EMPLOYABLE AS A DNA ALKYLATING AGENT AND CAN BE INCORPORATED INTO ANALOGS OF CC-1065 AND THE DUOCARMYCINS FOR THE SCRIPPS RESEARCH INSTITUTE (US) 1999-11-16 US disclosed
EP-0888301-A1 MCBI ANALOGS OF CC-1065 AND THE DUOCARMYCINS The Scripps Research Institute (US) 1999-01-07 EP disclosed
WO-1997032850-A1 MCBI ANALOGS OF CC-1065 AND THE DUOCARMYCINS THE SCRIPPS RESEARCH INSTITUTE (US) 1997-09-12 WO disclosed