Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL223631 | 1.00 | POLB (0.59) | POLBGAAALOX12KMT2AMEN1 | |
| SCHEMBL5575317 | 1.00 | POLB (0.59) | POLBGAAALOX12KMT2AMEN1 | |
| SCHEMBL3192032 | 1.00 | POLB (0.59) | POLBGAAALOX12KMT2AMEN1 | |
| SCHEMBL98457 | 1.00 | POLB (0.59) | POLBGAAALOX12KMT2AMEN1 | |
| SCHEMBL17816948 | 0.85 | POLB (0.59) | POLBGAAALOX12KMT2AMEN1 | |
| SCHEMBL15143001 | 0.85 | POLB (0.59) | POLBGAAALOX12KMT2AMEN1 | |
| SCHEMBL4124556 | 0.85 | POLB (0.59) | POLBGAAALOX12KMT2AMEN1 | |
| SCHEMBL6479731 | 0.85 | POLB (0.59) | POLBGAAALOX12KMT2AMEN1 | |
| SCHEMBL7158782 | 0.83 | POLB (0.58) | POLBGAAALOX12KMT2AMEN1 | |
| SCHEMBL6714428 | 0.83 | POLB (0.58) | POLBGAAALOX12KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603901-A1 | TETRAHYDROPYRAN COMPOUNDS AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 2005-12-14 | — | — | EP | disclosed |
| WO-2004078750-A1 | TETRAHYDROPYRAN COMPOUNDS AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 2004-09-16 | — | — | WO | disclosed |