Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 15/20 | 0.57 |
| ▸ | GSK3A | P49840 | 5/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | ALPL | P05186 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6363280 | 0.87 | GSK3B (0.65) | GSK3BGSK3AADORA1KDM4EMAPT | |
| SCHEMBL6363291 | 0.87 | GSK3B (0.65) | GSK3BGSK3AADORA1KDM4EMAPT | |
| SCHEMBL8342954 | 0.86 | GSK3B (0.71) | GSK3BGSK3AADORA1KDM4EALDH1A1 | |
| SCHEMBL6071654 | 0.84 | GSK3B (0.67) | GSK3BGSK3AADORA1MAPTMEN1 | |
| SCHEMBL6071675 | 0.84 | GSK3B (0.67) | GSK3BGSK3AADORA1MAPTMEN1 | |
| SCHEMBL8344273 | 0.84 | GSK3B (0.61) | GSK3BGSK3AADORA1ALDH1A1MAPT | |
| SCHEMBL6363435 | 0.83 | GSK3B (0.59) | GSK3BGSK3AADORA1 | |
| SCHEMBL6363440 | 0.83 | GSK3B (0.59) | GSK3BGSK3AADORA1 | |
| SCHEMBL6368829 | 0.77 | GSK3B (0.79) | GSK3BGSK3AADORA1KDM4EALDH1A1 | |
| SCHEMBL6363383 | 0.77 | GSK3B (0.78) | GSK3BGSK3AADORA1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551841-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |