Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6956321 | 1.00 | MAPT (0.47) | MAPTRAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL5155354 | 1.00 | MAPT (0.47) | MAPTRAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL5155472 | 0.89 | MAPT (0.50) | MAPTRAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL6959947 | 0.88 | PLA2G4B (0.42) | RAB9ASMN1; SMN2NPC1MAPK1TSHR | |
| SCHEMBL5365043 | 0.88 | PLA2G4B (0.42) | RAB9ASMN1; SMN2NPC1MAPK1TSHR | |
| SCHEMBL2433390 | 0.84 | MAPT (0.53) | MAPTRAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL2433389 | 0.84 | MAPT (0.53) | MAPTRAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL14592489 | 0.83 | MAPT (0.51) | MAPTRAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL5153100 | 0.81 | MAPT (0.50) | MAPTRAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL2437353 | 0.81 | MAPT (0.50) | MAPTRAB9ASMN1; SMN2NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189612-A4 | VLA-4 INHIBITOR COMPOUNDS | DAIICHI SEIYAKU CO (JP) | 2005-02-16 | — | — | EP | disclosed |
| EP-1189612-A1 | VLA-4 INHIBITOR COMPOUNDS | Daiichi Pharmaceutical Co., Ltd. (JP) | 2002-03-27 | — | — | EP | disclosed |
| WO-2001000206-A1 | VLA-4 INHIBITOR COMPOUNDS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2001-01-04 | — | — | WO | disclosed |