⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7216532 | 0.66 | CYP19A1 (0.35) | — | |
| SCHEMBL7962744 | 0.64 | — | — | |
| SCHEMBL4143118 | 0.60 | — | — | |
| SCHEMBL4078808 | 0.60 | — | — | |
| SCHEMBL5619234 | 0.58 | — | — | |
| SCHEMBL31537953 | 0.54 | — | — | |
| SCHEMBL8776640 | 0.51 | — | — | |
| SCHEMBL8723997 | 0.51 | — | — | |
| SCHEMBL1720840 | 0.49 | — | — | |
| SCHEMBL13210386 | 0.47 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0907642-B1 | PHENYLAMINO-SUBSTITUTED TRICYCLIC DERIVATIVES FOR TREATMENT OF HYPERPROLIFERATIVE DISEASES | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| US-6335344-B1 | Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases | PFIZER INC. | 2002-01-01 | — | — | US | disclosed |