Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 17/20 | 0.48 |
| ▸ | DPP7 | Q9UHL4 | 9/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8225692 | 0.85 | DPP4 (0.59) | DPP4DPP7ALDH1A1KCNH2DPP8 | |
| SCHEMBL4703124 | 0.82 | DPP4 (0.47) | DPP4DPP7ALDH1A1KCNH2DPP8 | |
| SCHEMBL25660416 | 0.76 | SLC1A2 (0.37) | DPP4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6149488 | 0.75 | DPP4 (0.43) | DPP4DPP7ALDH1A1KCNH2 | |
| SCHEMBL5477707 | 0.72 | DPP4 (0.69) | DPP4DPP7KCNH2DPP8DPP9 | |
| SCHEMBL15203460 | 0.72 | DPP4 (0.69) | DPP4DPP7KCNH2DPP8DPP9 | |
| SCHEMBL23655651 | 0.71 | DPP4 (0.67) | DPP4DPP7KCNH2DPP8DPP9 | |
| SCHEMBL6820738 | 0.71 | DPP4 (0.67) | DPP4DPP7KCNH2DPP8DPP9 | |
| SCHEMBL15203483 | 0.71 | DPP4 (0.67) | DPP4DPP7KCNH2DPP8DPP9 | |
| SCHEMBL14392401 | 0.71 | DPP4 (0.67) | DPP4DPP7KCNH2DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567489-A1 | PYRROLIDIN-2-ONE DERIVATIVES AS INHIBITORS OF THROMBIN AND FACTOR XA | GLAXO GROUP LIMITED (GB) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004052851-A1 | PYRROLYDIN-2-ONE DERIVATIVES AS INHIBITORS OF THROMBIN AND FACTOR XA | GLAXO GROUP LIMITED (GB) | 2004-06-24 | — | — | WO | disclosed |