Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 15/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 14/20 | 0.46 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.43 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.43 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6207045 | 0.92 | MAP2K2 (0.47) | CHRNA7KCNH2CHRNA1CYP3A4CHRNB2 | |
| SCHEMBL29371646 | 0.92 | MAP2K2 (0.47) | CHRNA7KCNH2CHRNA1CYP3A4CHRNB2 | |
| Hydrochloric Acid SCHEMBL6206110 | 0.90 | CHRNA7 (0.48) | CHRNA7KCNH2CHRNA1CYP3A4CHRNB2 | |
| SCHEMBL6406299 | 0.90 | PIM1 (0.44) | CHRNA7KCNH2CHRNA1CYP3A4CHRNB2 | |
| SCHEMBL6205441 | 0.85 | CHRNA7 (0.46) | CHRNA7KCNH2CHRNA1CYP3A4CHRNB2 | |
| SCHEMBL6208038 | 0.85 | PIM1 (0.45) | MAP2K1MAP2K2PIM1CAMK2B | |
| SCHEMBL15598681 | 0.84 | CHRNA7 (0.44) | CHRNA7KCNH2CHRNA1CYP3A4CHRNB2 | |
| SCHEMBL6399647 | 0.83 | CHRNA7 (0.48) | CHRNA7KCNH2CHRNA1CYP3A4CHRNB2 | |
| SCHEMBL6399220 | 0.83 | CHRNA7 (0.43) | CHRNA7KCNH2CHRNA1CYP3A4CHRNB2 | |
| SCHEMBL6399299 | 0.82 | PIM1 (0.41) | MAP2K1MAP2K2PIM1CAMK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578736-A1 | MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL-PHENYLAMINE DERIVATIVES | Warner-Lambert Company LLC (US) | 2005-09-28 | — | — | EP | claimed |
| WO-2004056789-A1 | MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL PHENYLAMINE DERIVATES | WARNER-LAMBERT COMPANY LLC (US) | 2004-07-08 | — | — | WO | claimed |