Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 3/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8213580 | 0.82 | SMN1; SMN2 (0.49) | SMN1; SMN2MEN1KMT2APOLBGAA | |
| SCHEMBL13451733 | 0.80 | SMN1; SMN2 (0.48) | SMN1; SMN2MEN1KMT2APOLBGAA | |
| SCHEMBL2568385 | 0.80 | SMN1; SMN2 (0.48) | SMN1; SMN2MEN1KMT2APOLBGAA | |
| SCHEMBL10820749 | 0.80 | SMN1; SMN2 (0.48) | SMN1; SMN2MEN1KMT2APOLBGAA | |
| SCHEMBL2567250 | 0.80 | SMN1; SMN2 (0.48) | SMN1; SMN2MEN1KMT2APOLBGAA | |
| SCHEMBL85699 | 0.80 | SMN1; SMN2 (0.48) | SMN1; SMN2MEN1KMT2APOLBGAA | |
| SCHEMBL2827980 | 0.80 | SMN1; SMN2 (0.48) | SMN1; SMN2MEN1KMT2APOLBGAA | |
| SCHEMBL2822724 | 0.80 | SMN1; SMN2 (0.48) | SMN1; SMN2MEN1KMT2APOLBGAA | |
| SCHEMBL2823436 | 0.80 | SMN1; SMN2 (0.48) | SMN1; SMN2MEN1KMT2APOLBGAA | |
| SCHEMBL2570631 | 0.80 | SMN1; SMN2 (0.48) | SMN1; SMN2MEN1KMT2APOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606268-A1 | HETEROCYCLIC KINASE INHIBITORS | Abbott Laboratories (US) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004076424-A1 | HETEROCYCLIC KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2004-09-10 | — | — | WO | disclosed |