Sugi Predict

Sugi Predict / Compounds / SCHEMBL6208778

SCHEMBL6208778

SCHEMBL6208778

CNCCNc1c(-c2nc3cc(N4CCN(S(C)(=O)=O)CC4)ccc3[nH]2)c(=O)[nH]c2ccc(Cl)cc12

nearest known ligand 0.50

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ PDGFRB P09619 9/20 0.50
▸ FGFR1 P11362 9/20 0.50
▸ KDR P35968 9/20 0.50
▸ CHEK1 O14757 7/20 0.46
▸ IGF1R P08069 1/20 0.40
▸ CYP3A4 P08684 1/20 0.40
▸ HRH4 Q9H3N8 3/20 0.40
▸ FLT1 P17948 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3384547 0.90 FGFR1 (0.61) PDGFRBFGFR1KDRCHEK1HRH4
SCHEMBL3381569 0.88 FGFR1 (0.52) PDGFRBFGFR1KDRCHEK1CYP3A4
SCHEMBL14798443 0.84 CHEK1 (0.52) PDGFRBFGFR1KDRCHEK1HRH4
SCHEMBL5411535 0.83 KDM4E (0.45) PDGFRBFGFR1KDRCHEK1IGF1R
SCHEMBL14795509 0.83 FGFR1 (0.47) PDGFRBFGFR1KDRCHEK1IGF1R
SCHEMBL3379919 0.81 FGFR1 (0.60) PDGFRBFGFR1KDRCHEK1HRH4
SCHEMBL3383756 0.81 FGFR1 (0.60) PDGFRBFGFR1KDRCHEK1HRH4
SCHEMBL15911047 0.81 FGFR1 (0.60) PDGFRBFGFR1KDRCHEK1HRH4
SCHEMBL14795357 0.79 CHEK1 (0.49) PDGFRBFGFR1KDRCHEK1HRH4
SCHEMBL3381258 0.79 FGFR1 (0.51) PDGFRBFGFR1KDRCHEK1FLT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1317442-B1 QUINOLINONE DERIVATIVES AS TYROSINE KINASE INHIBITORS CHIRON CORP (US) 2005-11-16 — — EP disclosed