Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 20/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6206394 | 0.79 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL6205548 | 0.79 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL6237250 | 0.77 | AKR1B1 (0.58) | AKR1B1 | |
| SCHEMBL6205244 | 0.75 | AKR1B1 (0.69) | AKR1B1 | |
| SCHEMBL7295107 | 0.72 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL6205848 | 0.71 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL6206187 | 0.71 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL4462998 | 0.70 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL6206599 | 0.69 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL6207869 | 0.69 | AKR1B1 (1.00) | AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1236720-B1 | Sulfonyl pyridazinone compounds useful as aldose reductase inhibitors | PFIZER PROD INC (US) | 2005-06-15 | — | — | EP | disclosed |
| EP-1260224-B1 | Sulfonyl pyridazinone compounds as therapeutic agents for ischemic tissue damage | PFIZER PROD INC (US) | 2005-02-23 | — | — | EP | disclosed |
| CN-1505514-A | Combination of aldose reductase inhibitors with cyclooxygenase-2 inhibitors | �Ʒ� | 2004-06-16 | — | — | CN | disclosed |
| US-6730674-B2 | ANTIDIABETIC AGENTS | PFIZER INC | 2004-05-04 | — | — | US | disclosed |
| CN-1390547-A | Therapy for tissue damage by local ischemia | PFIZER (US) | 2003-01-15 | — | — | CN | disclosed |
| EP-1260224-A1 | Sulfonyl pyridazinone compounds as therapeutic agents for ischemic tissue damage | Pfizer Products Inc. (US) | 2002-11-27 | — | — | EP | disclosed |
| EP-1236720-A1 | Sulfonyl pyridazinone compounds useful as aldose reductase inhibitors | Pfizer Products Inc. (US) | 2002-09-04 | — | — | EP | disclosed |